I Told You So
-
The ID-1 gene is responsible for making cancers more aggressive and difficult to treat. Interestingly, CBD can mitigate the ID-1 gene, a discovery that was made in 2007 but subsequently overlooked.
In a 2007 study, cannabidiol (CBD) was identified as a potential inhibitor of the ID-1 gene in aggressive breast cancer cells. It suggested that CBD, a compound with low toxicity, could reduce ID-1 expression in these cells. This discovery is of great significance as aggressive breast cancer cells become less invasive when ID-1 is down-regulated. The study concluded that CBD could be the first non-toxic external agent that can significantly decrease Id-1 expression, thereby reducing the aggressiveness of the tumor.
In 2012, the study was rediscovered and reported on, emphasizing that CBD only works on cancer cells with high levels of ID-1. These include aggressive, metastatic cells found in various cancers such as leukemia, colorectal, pancreatic, lung, ovarian, brain, and others.
Fifteen years after the original study, the research was replicated with identical impressive results. The cells stopped behaving erratically and returned to a normal state. CBD was found to inhibit the aggressive behavior of cancer cells triggered by the inflammatory cytokine IL-1β.
Using CBD in cancer treatment is a revolutionary approach, differing from chemotherapy which aims to poison the cancer, hoping it dies before the patient does. CBD and other cannabinoids can potentially make chemotherapy more effective. A therapy involving cannabinoids, which has low toxicity and can directly reduce tumor activity and sensitize tumors to existing treatments, is an attractive option for cancer treatment.
CBD is undervalued in its potential role in cancer treatment!
-
A remarkable case of lung cancer reacting positively to self-treatment with cannabidiol, a non-psychoactive element found in Cannabis sativa, has been noted. Despite advancements in new medication, lung cancer prognosis remains grim. Even though targeted therapies are enhancing results, it's not rare for patients to only have a partial response and relapse during follow-up. This highlights the need for new drugs or the reassessment of existing treatments for other non-cancerous diseases. It's crucial to be aware of patients who respond well to non-standard treatments. A patient with lung adenocarcinoma showed tumor response after self-administering cannabidiol, having declined chemotherapy and radiotherapy. Previous studies have indicated that cannabidiol may have anti-cancer properties and boost the immune response to cancer. The evidence suggests that cannabidiol could have led to a significant response in a lung cancer patient.
The use of the term "striking" in the title by the scientists is quite unusual and suggests their astonishment.
Despite significant advancements in lung cancer treatment, it remains the most persistent form of cancer and the leading cause of cancer-related deaths globally. The current therapeutic interventions are only partially effective, emphasizing the need for continual exploration for novel and more efficient treatments. Tumor angiogenesis and cancer stem cells are instrumental in cancer initiation and propagation. Tumor angiogenesis is activated when pro-angiogenic factors surpass anti-angiogenic components. Although numerous anti-angiogenic agents are used in cancer treatment, they have therapeutic limitations and significant side effects. Cannabinoids, particularly cannabidiol (CBD), have been extensively studied recently for their potential anti-cancer effects. CBD has been found to hinder tumor growth in mouse models of melanoma and glioblastoma. Importantly, CBD is believed to possess anti-angiogenic activity. In this research, inhalant CBD was tested for the first time in the treatment of heterotopic lung cancer to see if it could reduce the number of cancer stem cells and inhibit tumor angiogenesis. The study found that CBD decreased the rate of tumor growth and suppressed the expression of CD44 and angiogenic factors VEGF and P-selectin, suggesting that inhalant CBD could hinder lung cancer growth by suppressing CD44 and angiogenesis.
-
The hemp extract has shown promising results in hair regrowth, outperforming contemporary medical treatments. This has been observed in just half a year, demonstrating impressive progress for someone who was previously bald. It's also proven effective for females. Note, the individual mentioned is not the speaker.
-
Here's a handy shortcut to a webpage that provides details on Cannabinoids, explaining their biochemical processes. This particular page focuses on endocannabinoids and their role in regulating eating habits and maintaining energy balance.
-
A user mentioned sharing a quote from a study about the Endocannabinoid System and its role in anxiety and depression. The study found the effectiveness of cannabinoid compounds to be comparable to known antidepressants, but only at a low dosage. It was suggested that taking too much could potentially increase feelings of depression and anxiety. The user contemplates collecting all the relevant scientific research, with the intention of presenting it to the local legislature in an attempt to push for the legalization of medical marijuana, arguing that not everyone can tolerate traditional pain medications like opiates.
-
The article raises some concerns, particularly the part where it says, "Cannabidiol's biological activities are due to either its inhibition of anandamide degradation, its antioxidant attributes, or its interaction with as yet unidentified cannabinoid receptors". This statement prompts further research because it doesn't fully align with my understanding. Other sources suggest cannabidiol has a higher affinity for CB2 than CB1 receptors.
There's a lot of conflicting information out there, with some sources claiming cannabidiol acts as an antagonist, while others suggest it has agonist activity on CB2. It's a complicated field, and the accurate interpretation is still uncertain due to government restrictions on research and biochemistry that keep us in the dark.
Cannabidiol is primarily active in CB2 as a negative allosteric modulator, a CB2 Antagonist. Its metabolism boosts intracellular enzymes (Epoxides and Fatty acid binding proteins) that help degrade the lipid through lipid signalling. With sufficient cannabidiol in the system, it can communicate with CB1 receptors through lipid rafts and Cytokines.
The metabolism of phytocannabinoids is non-selective, unlike endocannabinoids which are selective and can choose for CB receptors. The medical biochemistry resource is close to explaining this, but not perfect.
Another factor that's not typically considered in cannabidiol research is Chirality! Cannabidiol can dock into CB receptors in about four different ways depending on how it expresses when interacting with the CB receptors. As a three-dimensional shape, the four sides are slightly different.
-
The growth of new brain cells is stimulated by cannabis...
Cannabinoids and their role in neurogenesis: Could they be the answer to neurodegeneration?haha
-
Cannabidiol helps to reduce depressive symptoms by regulating the differentiation of neural stem cells.
-
A while ago, when the Document was only about 500 pages long, an individual printed it all out and displayed it to all at a local festival. The sound it made when he placed it on a table was quite substantial, and it certainly got people's attention, showing them that there are numerous researches conducted on cannabis.
-
The text suggests that cannabis can promote hair regrowth more effectively than current medical treatments. It refers to a study where a unique hemp extract was used for hair regrowth, showing significant results within half a year. This treatment seems to be efficient for both men and women, even those who were previously bald. The text also humorously suggests using hair from various body parts, such as ears, eyebrows, and nose, for hair transplantation due to their rapid growth.
-
The mentor enthusiastically declared, "@Storm Crow, you are the expert!"
-
@Storm Crow, my guide has acknowledged your expertise!
-
Your contribution is vital in achieving remarkable outcomes. My presence, however, may not yield positive results. I'm quite outspoken, which is why my children think I'm losing my memory, because I don't censor my speech. I've come to realise that the support I had as a child is no longer there. I've been too passive all my life and I'm tired of it. I should have stood up for myself from the beginning. I blame myself for trusting my children when they told me I could use one of their cars, as they didn't have space for a third vehicle. However, I now realise that I need to get a third car, as my daughter will start driving next year. She plans to use the Camry Hybrid for her commute to university. She also believes that her aunt will allow her to move in, which is amusing. My other daughter has explicitly stated that she doesn't want to share her living space. Even though both my children are university graduates, they still manage to cause me distress and disappointment in other ways.
-
Cannabidiol helps in mitigating depressive tendencies by regulating the differentiation of neural stem cells.
-
The post asserts that cannabis has a superior effect in promoting hair regrowth compared to contemporary medicine. The evidence presented involves a case series of successful hair regrowth using a unique hemp extract, particularly noteworthy in a previously bald man within a span of six months. The results are not limited to men but also extend to women. The poster humorously suggests a solution to baldness could be transplanting hair from areas like the ears, eyebrows, and nose, as those regions seem to have a rapid hair growth rate.
-
The user shared an interesting discovery that cannabis can promote hair regrowth more effectively than contemporary medical treatments. They mentioned a case study about hair regrowth using a unique hemp extract, showing impressive results within just six months. This treatment seems to work not only for men but also for women. The user jokingly clarified that they aren't the individual in the pictures, and they've shared the information with their daughter, whose husband is experiencing hair loss.
-
The growth of new brain cells is promoted by cannabinoids... Could this be the long-awaited answer to neurodegeneration?
-
Here's a speedy connection to a page that provides information about Cannabinoids, explaining their biochemical processes. It focuses on endocannabinoids and their role in feeding behaviour and maintaining energy balance.
-
Is the reason I consistently overlooked my anti-depressant medication due to my CBD gummy intake? I stumbled upon some information recently and wanted to share it here as well, so as not to misguide anyone.
This information was derived from a study regarding the Endocannabinoid System and its relation to depression and anxiety when influenced by external cannabinoids.
The study found that the effectiveness of these cannabinoid substances was on par with certain recognized antidepressants. Mostly, these beneficial impacts on depression and anxiety were noted at relatively lower doses of cannabinoids which activated CB1R. Conversely, higher doses often resulted in increased depression and anxiety.
Just as the proverb goes, moderation is key.
-
The mentor voiced their admiration for Storm Crow, declaring them to be an expert.