I Told You So
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This discussion is centred on the various advantages associated with cannabis that I've previously outlined. Feel free to contribute additional benefits if you wish.
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Here's a swift access to a webpage that gives detailed information about Cannabinoids, explaining their biochemical processes. It discusses endocannabinoids on a medical biochemistry page and delves into their role in eating habits and maintaining energy balance.
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The regrowth of hair using a unique hemp extract surpasses the results of contemporary medicine.
Revitalizing Hair with Innovative Cannabis Extract: A Collection of Cases
This outcome was achieved within just half a year. Impressive for someone previously bald! It's also effective for women. Just to clarify, the subject isn't me.
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This discussion revolves around the various advantages of cannabis that I've previously pointed out. Feel free to contribute additional benefits if you wish.
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Breast cancer can become more aggressive and difficult to treat due to the ID-1 gene. The compound Cannabidiol (CBD) has been shown to "neutralise" this gene. This was first observed in 2007 but has since been overlooked.
Cannabidiol has been studied as a new inhibitor of the Id-1 gene in aggressive breast cancer cells. Aggressive breast cancer cell invasion and metastasis is the last and fatal stage of cancer progression, which is poorly understood genetically. Clinically, there are limited therapies for aggressive and metastatic breast cancers. Id-1, which inhibits basic helix-loop-helix transcription factors, has been identified as a key regulator of the metastatic potential of breast and other cancers. We found that metastatic breast cancer cells became significantly less invasive and less metastatic when Id-1 was down-regulated. However, it's currently impossible to reduce Id-1 expression in patients with metastatic breast cancer using antisense technology. Our study revealed that CBD, a cannabinoid with a low-toxicity profile, can down-regulate Id-1 expression in aggressive human breast cancer cells.
In 2012, some journalists discovered this study and reported it as a potential tool against cancer. The study indicated that when the cancer cells were exposed to cannabidiol, not only did they stop behaving erratically, but they also began to return to a normal state.
Fast forward to 15 years later, the same study was repeated with the same astounding results! The cells stopped behaving erratically and they also returned to a normal state!
A study in 2020 showed that CBD can revert the invasive behaviour of breast cancer cells brought about by the inflammatory cytokine IL-1β. CBD was found to reduce cell viability, block migration, and halt the progression of the IL-1β-induced signalling pathway. It also restored the cells' epithelial organization and prevented nuclear translocation of β-catenin, a key player in the EMT pathway.
Chemotherapy poisons the cancer, with the hope that the cancer will die before the patient. But if you do choose chemotherapy, CBD and other cannabinoids may help your chemotherapy work better.
The antitumor activity of plant-derived non-psychoactive cannabinoids like CBD is a promising therapeutic modality due to their low toxicity profile and ability to sensitize tumors to existing first-line agents.
CBD deserves more recognition!
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The substances CBDA and THCA found in cannabis are shown to have protective qualities and could potentially reverse Alzheimer's disease.
In a study conducted using a mouse model that simulates Alzheimer's disease, CBDA and THCA were observed to improve memory deficits and decrease Amyloid-Beta and Tau presence - two key markers of Alzheimer's. Mice that were treated with CBDA and THCA demonstrated superior cognitive function and lower levels of Amyloid-Beta and Tau compared to those treated with A_1–42. Further, these cannabinoids mitigated calcium imbalance and exhibited protective effects on primary neurons. The research suggests that CBDA and THCA could effectively counteract Alzheimer's disease by improving memory and resilience to increased levels of calcium, Amyloid-Beta, and Tau in the hippocampus. This implies that these cannabinoids could be beneficial therapeutic agents for treating Alzheimer's disease.
Related research on cannabinoids in neurodegenerative disorders and stroke/brain trauma shows promise for both acute and chronic neurodegenerative conditions. Accumulated experimental evidence, mainly at the preclinical stage, supports the potential neuroprotective properties of various cannabinoid compounds in adult and neonatal ischemia, brain trauma, Alzheimer’s disease, Parkinson’s disease, Huntington’s chorea, and amyotrophic lateral sclerosis.
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Galaxy420 has shared a link to a webpage that provides detailed information on cannabinoids and their biochemical pathways. The article discusses endocannabinoids and their role in controlling feeding behaviour and energy homeostasis. The writer mentions that the article is extensive and could be likened to a comprehensive chapter. They further express reservations about the statement that cannabidiol doesn't interact significantly with CB1 or CB2 receptors. The writer's doubt stems from the fact that the biological activities of cannabidiol are attributed to the inhibition of anandamide degradation, its antioxidant properties, or interaction with yet-to-be-identified cannabinoid receptors. They disagree with this and have referenced another study that suggests cannabidiol has a higher affinity for CB2 than for CB1. They also point out the conflicting views from different studies, with some suggesting that cannabidiol is an antagonist for its counterpart, while others argue it exhibits agonist activity on CB2.
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The ID-1 gene is responsible for making cancers more aggressive and difficult to treat. Interestingly, CBD can mitigate the ID-1 gene, a discovery that was made in 2007 but subsequently overlooked.
In a 2007 study, cannabidiol (CBD) was identified as a potential inhibitor of the ID-1 gene in aggressive breast cancer cells. It suggested that CBD, a compound with low toxicity, could reduce ID-1 expression in these cells. This discovery is of great significance as aggressive breast cancer cells become less invasive when ID-1 is down-regulated. The study concluded that CBD could be the first non-toxic external agent that can significantly decrease Id-1 expression, thereby reducing the aggressiveness of the tumor.
In 2012, the study was rediscovered and reported on, emphasizing that CBD only works on cancer cells with high levels of ID-1. These include aggressive, metastatic cells found in various cancers such as leukemia, colorectal, pancreatic, lung, ovarian, brain, and others.
Fifteen years after the original study, the research was replicated with identical impressive results. The cells stopped behaving erratically and returned to a normal state. CBD was found to inhibit the aggressive behavior of cancer cells triggered by the inflammatory cytokine IL-1β.
Using CBD in cancer treatment is a revolutionary approach, differing from chemotherapy which aims to poison the cancer, hoping it dies before the patient does. CBD and other cannabinoids can potentially make chemotherapy more effective. A therapy involving cannabinoids, which has low toxicity and can directly reduce tumor activity and sensitize tumors to existing treatments, is an attractive option for cancer treatment.
CBD is undervalued in its potential role in cancer treatment!
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A remarkable case of lung cancer reacting positively to self-treatment with cannabidiol, a non-psychoactive element found in Cannabis sativa, has been noted. Despite advancements in new medication, lung cancer prognosis remains grim. Even though targeted therapies are enhancing results, it's not rare for patients to only have a partial response and relapse during follow-up. This highlights the need for new drugs or the reassessment of existing treatments for other non-cancerous diseases. It's crucial to be aware of patients who respond well to non-standard treatments. A patient with lung adenocarcinoma showed tumor response after self-administering cannabidiol, having declined chemotherapy and radiotherapy. Previous studies have indicated that cannabidiol may have anti-cancer properties and boost the immune response to cancer. The evidence suggests that cannabidiol could have led to a significant response in a lung cancer patient.
The use of the term "striking" in the title by the scientists is quite unusual and suggests their astonishment.
Despite significant advancements in lung cancer treatment, it remains the most persistent form of cancer and the leading cause of cancer-related deaths globally. The current therapeutic interventions are only partially effective, emphasizing the need for continual exploration for novel and more efficient treatments. Tumor angiogenesis and cancer stem cells are instrumental in cancer initiation and propagation. Tumor angiogenesis is activated when pro-angiogenic factors surpass anti-angiogenic components. Although numerous anti-angiogenic agents are used in cancer treatment, they have therapeutic limitations and significant side effects. Cannabinoids, particularly cannabidiol (CBD), have been extensively studied recently for their potential anti-cancer effects. CBD has been found to hinder tumor growth in mouse models of melanoma and glioblastoma. Importantly, CBD is believed to possess anti-angiogenic activity. In this research, inhalant CBD was tested for the first time in the treatment of heterotopic lung cancer to see if it could reduce the number of cancer stem cells and inhibit tumor angiogenesis. The study found that CBD decreased the rate of tumor growth and suppressed the expression of CD44 and angiogenic factors VEGF and P-selectin, suggesting that inhalant CBD could hinder lung cancer growth by suppressing CD44 and angiogenesis.
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The hemp extract has shown promising results in hair regrowth, outperforming contemporary medical treatments. This has been observed in just half a year, demonstrating impressive progress for someone who was previously bald. It's also proven effective for females. Note, the individual mentioned is not the speaker.
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Here's a handy shortcut to a webpage that provides details on Cannabinoids, explaining their biochemical processes. This particular page focuses on endocannabinoids and their role in regulating eating habits and maintaining energy balance.
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A user mentioned sharing a quote from a study about the Endocannabinoid System and its role in anxiety and depression. The study found the effectiveness of cannabinoid compounds to be comparable to known antidepressants, but only at a low dosage. It was suggested that taking too much could potentially increase feelings of depression and anxiety. The user contemplates collecting all the relevant scientific research, with the intention of presenting it to the local legislature in an attempt to push for the legalization of medical marijuana, arguing that not everyone can tolerate traditional pain medications like opiates.
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The article raises some concerns, particularly the part where it says, "Cannabidiol's biological activities are due to either its inhibition of anandamide degradation, its antioxidant attributes, or its interaction with as yet unidentified cannabinoid receptors". This statement prompts further research because it doesn't fully align with my understanding. Other sources suggest cannabidiol has a higher affinity for CB2 than CB1 receptors.
There's a lot of conflicting information out there, with some sources claiming cannabidiol acts as an antagonist, while others suggest it has agonist activity on CB2. It's a complicated field, and the accurate interpretation is still uncertain due to government restrictions on research and biochemistry that keep us in the dark.
Cannabidiol is primarily active in CB2 as a negative allosteric modulator, a CB2 Antagonist. Its metabolism boosts intracellular enzymes (Epoxides and Fatty acid binding proteins) that help degrade the lipid through lipid signalling. With sufficient cannabidiol in the system, it can communicate with CB1 receptors through lipid rafts and Cytokines.
The metabolism of phytocannabinoids is non-selective, unlike endocannabinoids which are selective and can choose for CB receptors. The medical biochemistry resource is close to explaining this, but not perfect.
Another factor that's not typically considered in cannabidiol research is Chirality! Cannabidiol can dock into CB receptors in about four different ways depending on how it expresses when interacting with the CB receptors. As a three-dimensional shape, the four sides are slightly different.
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The growth of new brain cells is stimulated by cannabis...
Cannabinoids and their role in neurogenesis: Could they be the answer to neurodegeneration?haha
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Cannabidiol helps to reduce depressive symptoms by regulating the differentiation of neural stem cells.
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A while ago, when the Document was only about 500 pages long, an individual printed it all out and displayed it to all at a local festival. The sound it made when he placed it on a table was quite substantial, and it certainly got people's attention, showing them that there are numerous researches conducted on cannabis.
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The text suggests that cannabis can promote hair regrowth more effectively than current medical treatments. It refers to a study where a unique hemp extract was used for hair regrowth, showing significant results within half a year. This treatment seems to be efficient for both men and women, even those who were previously bald. The text also humorously suggests using hair from various body parts, such as ears, eyebrows, and nose, for hair transplantation due to their rapid growth.
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The mentor enthusiastically declared, "@Storm Crow, you are the expert!"
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@Storm Crow, my guide has acknowledged your expertise!
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Your contribution is vital in achieving remarkable outcomes. My presence, however, may not yield positive results. I'm quite outspoken, which is why my children think I'm losing my memory, because I don't censor my speech. I've come to realise that the support I had as a child is no longer there. I've been too passive all my life and I'm tired of it. I should have stood up for myself from the beginning. I blame myself for trusting my children when they told me I could use one of their cars, as they didn't have space for a third vehicle. However, I now realise that I need to get a third car, as my daughter will start driving next year. She plans to use the Camry Hybrid for her commute to university. She also believes that her aunt will allow her to move in, which is amusing. My other daughter has explicitly stated that she doesn't want to share her living space. Even though both my children are university graduates, they still manage to cause me distress and disappointment in other ways.