I Told You So
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A user referred to a comprehensive page on cannabinoids, specifically focusing on endocannabinoids' role in feeding behaviour and energy balance. They found the article lengthy, akin to a chapter, but expressed concerns over a particular statement about cannabidiol (CBD). The statement suggested that CBD doesn't significantly interact with CB1 or CB2 receptors, with its biological effects attributed to either the inhibition of anandamide degradation, antioxidant properties, or interactions with unidentified cannabinoid receptors. The user disagreed with this statement, citing another source indicating CBD has a higher affinity for CB2 than CB1. The user also mentioned conflicting research suggesting CBD's antagonist or agonist activity on CB2.
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A pair's investigation into lung cancer-
Remarkable lung cancer response to self-administered cannabidiol: A case study and literature analysis. (UK) (full – 2019) Remarkable lung cancer response to self-administered cannabidiol: A case study and literature analysis
Despite advancements in medicine, lung cancer prognosis remains bleak. While targeted treatments have improved outcomes, it's not uncommon for many patients to only partially respond and relapse during follow-up. Therefore, the need for new drugs or reassessment of existing therapies for other non-cancerous diseases (drug repurposing) is urgent. It is critical, while conducting this research in vitro and in vivo, to remain observant of patients who show a positive response to non-standard treatments. We document here a lung adenocarcinoma patient who, having declined chemotherapy and radiotherapy, exhibited tumour response following self-administration of cannabidiol, a non-psychoactive compound in Cannabis sativa. Previous studies have suggested that cannabidiol may possess anti-cancer properties and boost the immune response to cancer. The data presented here suggest that cannabidiol may have induced a remarkable response in a lung cancer patient.
The use of the word "remarkable" in the title by the scientists is quite atypical. It appears their expectations were significantly exceeded!
Inhaled cannabidiol hinders tumour growth by reducing tumour stemness and impairing angiogenic switch in NCI-H1437-induced human lung cancer model. (USA/ Belgium) (abst – 2023) https://link.springer.com/article/10.1007/s13577-023-00869-8
Lung cancer remains the most persistent type of cancer and the primary cause of cancer death globally. Despite substantial advancements in lung cancer treatment, current therapeutic interventions are only partially successful, thus highlighting the need for more effective, innovative alternative treatments. Angiogenesis and cancer stem cells are critical in the onset and progression of cancers. Tumour angiogenesis is initiated by an angiogenic switch when pro-angiogenic factors surpass anti-angiogenic elements. Although numerous anti-angiogenic agents are used in cancer treatment, their therapeutic effectiveness is constrained by significant side effects. Recently, cannabinoids have been extensively studied for their potential anti-cancer effects. Our prior results indicated that cannabidiol (CBD) could hinder tumour growth in mouse models of melanoma and glioblastoma. Notably, CBD has been suggested to exhibit anti-angiogenic activity. In this study, we assessed, for the first time, inhaled CBD in the treatment of heterotopic lung cancer and whether such potential effects could decrease cancer stem cell numbers and inhibit tumour angiogenesis. We implanted NCI H1437 human lung cancer cells in nude mice and treated the mice with inhaled CBD or placebo. The results were evaluated by tumour size and imaging, as well as by immunohistochemistry and flow cytometric analysis for CD44, VEGF, and P-selectin. Our findings demonstrated that CBD reduced the tumour growth rate and suppressed the expression of CD44 and the angiogenic factors VEGF and P-selectin. These findings suggest, for the first time, that inhaled CBD can hinder lung cancer growth by suppressing CD44 and angiogenesis.
From Granny
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I appreciate the information. I'm genuinely considering collecting as much scientific research as possible, hiring a truck, and delivering it all to a local Australian legislative assembly, saying, "Here's the research you requested." Now, the least they could do is legalize medicinal use. Some individuals are unable to use opioids for pain relief. Achieving significant outcomes like these requires people with your kind of dedication. If I were to personally make an appearance there... that may not end well.
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This discussion focuses on the various advantages of cannabis I've previously noted. Feel free to contribute additional benefits.
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The statement is about the potential of cannabis in promoting hair growth, which appears to be more effective than contemporary medical treatments. There's a case series that illustrates this using hemp extract. The results after only half a year are impressive, even for individuals who were previously bald, and it's not just effective for men, but women as well. This information was shared with a family member whose spouse is experiencing hair loss.
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Galaxy420 shared a link to a webpage detailing Cannabinoid information, particularly on the topic of endocannabinoids and their role in managing feeding behaviour and energy balance. They found the article quite lengthy, akin to a chapter in a book. They expressed uncertainty regarding a statement in the article which suggested that cannabidiol doesn't interact significantly with CB1 or CB2 receptors. Their confusion also stems from different sources providing contrasting views on whether cannabidiol functions as an antagonist or an agonist.
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The user discussed a study they read called "Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review". It described how certain cannabinoid compounds could be as effective as certain known antidepressants. The study found that the positive impact on depression and anxiety was observed at lower doses while higher doses could potentially have opposite effects. The user reminded others about the importance of moderation in consumption.
The user is also considering collecting available scientific data on the topic and presenting it to the local legislative body, urging them to legalise medical cannabis, as it might be a viable alternative for individuals who cannot tolerate opiates for pain relief.
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Here's a couple of interesting studies on lung cancer:
A significant response to self-administered cannabidiol, a non-psychoactive compound present in Cannabis sativa, was observed in a lung cancer patient. This is despite the prognosis for lung cancer typically being poor, even with the advent of new drugs. Many patients only see a partial improvement and often relapse. Therefore, the need for new or repurposed drugs is evident. The patient, who declined conventional treatments like chemotherapy and radiotherapy, showed a notable decrease in the size of the tumour after using cannabidiol. Previous research has already suggested that cannabidiol may possess properties that counteract cancer and boost the immune response to the disease. The findings presented here suggest that cannabidiol might have contributed significantly to the patient's response.
The choice of the term "striking" in the research title was quite unique, possibly indicating the researchers' astonishment.
In another study, inhalant cannabidiol was found to inhibit tumour growth by reducing cancer stem cell numbers and hindering tumour angiogenesis in a human lung cancer model. The current treatments for lung cancer, the most chronic form of cancer and leading cause of cancer-related deaths globally, are only partially effective. Hence, the search for better alternatives continues. Tumour angiogenesis, a process triggered by an imbalance of pro-angiogenic and anti-angiogenic factors, and cancer stem cells are pivotal to the onset and proliferation of cancers. Although there are several anti-angiogenic agents used in cancer treatment, they come with significant side effects. Cannabinoids, particularly cannabidiol (CBD), have shown promise as potential anti-cancer agents in recent research. CBD was found to slow down tumour growth in cases of melanoma and glioblastoma. This research aimed to test the impact of inhaled CBD on lung cancer treatment, and the results showed a reduction in tumour growth, suppression of CD44 (a cancer stem cell marker), and the angiogenic factors VEGF and P-selectin. These findings suggest that inhalant CBD could serve as an effective treatment for lung cancer.
Granny
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The user mentioned that they read a study about the Endocannabinoid System and its potential impacts on depression and anxiety. The study found that certain cannabinoid compounds were as effective as some known antidepressants. However, the study also noted that low doses had more positive effects, while higher doses could potentially increase depression and anxiety. Thus, the user concluded, moderation is key.
In response to this, they are considering collecting as much scientific data as possible and presenting it to the local government body in hopes of prompting them to legalise medical marijuana for those who can't tolerate traditional pain medications.
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In the early days when the Directory was barely 500 pages, someone printed the entire thing and presented it at a local festival. The person claimed it made a significant sound when placed on a table, which helped some individuals realise the vast amount of research conducted on cannabis.
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Might my forgetfulness in taking my anti-depressants be linked to the consumption of CBD gummies? I recently stumbled upon some information that I feel is important to share here, for the sake of not misleading anyone.
This information comes from a research study focused on the impact of the endocannabinoid system and external cannabinoids on depression and anxiety. According to the study, the effectiveness of these cannabinoid substances was comparable to several well-known antidepressants. This positive impact on depression and anxiety was typically observed at relatively low doses of cannabinoids that activate CB1R. However, it's important to note that higher doses often had the opposite effect, exacerbating depression and anxiety.
Reiterating an old adage, it is always about balance - not too little, not too much.
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Cannabidiol possesses the ability to counter both enveloped and non-enveloped viruses, thus serving as a comprehensive antiviral agent.
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A claim has been made that cannabis promotes hair regrowth more effectively than contemporary medical treatments. There's a case study suggesting impressive results from a new hemp extract, with significant hair growth observed in a previously bald man within just half a year. The treatment is also effective for women. In a lighter note, there's a suggestion for those with excessive hair growth in areas like ears, eyebrows, and nose to consider using it for hair transplantation.
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A while ago, when the Catalogue was barely 500 pages long, someone actually printed out the entire document and showcased it during a festival. The sound it made when it hit a table was quite impactful, and it served to enlighten many people about the extensive amount of research done on cannabis.