I Told You So
-
Appreciate the information. I'm genuinely considering collecting as much scientific evidence as possible and hiring a truck to transport it to a legislative assembly in a major Australian city. I plan to present all the research and say, "Here are the investigations you requested." Now, at the very least, medical usage should be legalized. Certain individuals are unable to tolerate painkillers.
It requires individuals like yourself to accomplish such significant feats. If I were to appear there... well, that might not end well. -
Hemp extract appears to be an effective solution for hair regrowth, surpassing the successes of contemporary medical treatments. A recent case series demonstrates significant hair regrowth in just half a year. The results are impressive, even for those who were previously bald, and it's beneficial for both genders. These findings were so compelling that I felt compelled to share them with my daughter, whose husband is experiencing hair loss.
-
Could the reason why I continually overlooked taking my anti-depressants while consuming CBD gummies be due to the fact that CBD eases depression? It appears that Cannabidiol hinders depressive-like actions by influencing the development of neural stem cells.
-
It requires individuals like you to accomplish such incredible feats. My presence there would likely not be beneficial. I'm known for my directness, to the point where my children suspect I have Alzheimer's due to my unfiltered speech.
Growing up, I felt unsupported by my parents, and now I find myself without anyone to stand up for me. I've allowed others to walk all over me throughout my life and I'm tired of it. I now understand that I should have stood up for myself from the beginning and I regret trusting my children when they assured me that I could use one of their cars.
It's now clear that a third car is necessary, especially since my daughter will be driving soon. She'll be using the Camry Hybrid for her college commute. Interestingly, she believes she'll be able to live with her aunt, despite my other daughter expressing that she does not want anyone living with her.
Despite being college graduates, my children have found other ways to cause me disappointment and distress.
-
The text summarised: The statement "Cannabidiol (CBD) doesn't significantly interact with CB1 or CB2 receptors, its biological actions are due to either the inhibition of anandamide degradation, its antioxidant attributes, or its interaction with unknown cannabinoid receptors" is slightly troubling. There is a counter claim from another article saying "CBD has a greater affinity for CB2 than CB1". Multiple sources suggest activity, yet some argue that it acts as an antagonist, while others claim it has agonist activity on CB2.
The understanding is still murky and it's uncertain who has the correct interpretation, as government restrictions continue to hinder research efforts. CBD mainly acts in CB2 as a negative allosteric modulator or a CB2 antagonist. CBD metabolism enhances intracellular enzymes that degrade the lipid via lipid signalling. If CBD levels are high enough, it can communicate with CB1 through lipid rafts and cytokines.
The metabolism of plant-based cannabinoids isn't as selective as that of endocannabinoids, which can selectively interact with CB receptors. The medical biochemistry information is nearly accurate, however not completely. Another aspect often overlooked in CBD research is Chirality - CBD can connect with CB receptors in approximately four different ways depending on how it manifests when interacting with the CB receptors, given its three-dimensional shape.
-
Cannabis stimulates the growth of new brain cells... Cannabinoids and neurogenesis: Could this be the much-anticipated cure for neurodegeneration?
-
Cannabidiol has the potential to halt both enveloped and nonenveloped viruses, demonstrating a wide-ranging antiviral impact. Therefore, it's established.
-
Could the reason I kept overlooking my anti-depressant medication while consuming CBD edibles be due to CBD's ability to mitigate depressive symptoms by influencing neural stem cell differentiation?
-
Could the reason why I consistently overlooked my anti-depressant pills while consuming CBD-infused sweets be due to the fact that CBD eases depressive symptoms by regulating the differentiation of neural stem cells?
-
Cannabis may both guard against and potentially reverse Alzheimer's.
Substances found in cannabis, namely CBDA and THCA, can rescue memory impairments and decrease Amyloid-Beta and Tau pathology in mouse models that mimic Alzheimer's disease.
Mice treated with CBDA and THCA demonstrated lower hippocampal A_ and p-tau levels, and better cognitive function than mice treated with A_1–42. Furthermore, CBDA and THCA reduced A_ and p-tau levels, corrected calcium imbalance, and displayed neuroprotective effects in primary neurons. The data implies that CBDA and THCA have anti-Alzheimer's effects, and they soften memory loss and resilience to increased hippocampal Ca2+, A_, and p-tau levels. In conclusion, CBDA and THCA could potentially be effective therapeutic agents for Alzheimer's treatment.
Also of interest: The Role of Cannabinoids in Neurodegenerative Disorders and Brain Trauma: From Lab Models to Clinical Use
The potential benefit is significant for both acute and chronic neurodegenerative conditions. This overview collates all experimental evidence, primarily derived from preclinical studies, which support the idea that different cannabinoid compounds could be neuroprotective in adult and neonatal ischemia, brain trauma, Alzheimer's disease, Parkinson's disease, Huntington's chorea, and amyotrophic lateral sclerosis.
-
Cannabidiol has the potential to thwart various types of viruses, encompassing both enveloped and nonenveloped ones.
-
Cannabis may act as a guard and possible remedy for Alzheimer's disease.
Compounds found in cannabis, namely CBDA and THCA, have been shown to improve memory deficits and reduce key markers of Alzheimer's disease in a mouse model that mimics the condition. Mice treated with these compounds demonstrated decreased levels of Alzheimer's-associated proteins in the hippocampus and improved cognitive function, compared to those treated without these compounds. Moreover, CBDA and THCA reduced the levels of these harmful proteins, helped regulate calcium imbalance, and showed protective effects on neurons. Our findings indicate that these compounds can counteract Alzheimer's effects and lessen memory deterioration and susceptibility to increased levels of harmful proteins and calcium in the hippocampus. Thus, CBDA and THCA could be helpful therapeutic agents for managing Alzheimer's disease.
In addition to this, see: The Role of Cannabinoids in Neurological Disorders and Brain Injuries: From Lab Experiments to Clinical Uses.
The potential of these compounds is promising for treating both sudden and long-term neurodegenerative conditions. In this review, we will gather all experimental evidence, primarily from preclinical studies, supporting the notion that various cannabinoid compounds could be neuroprotective in adult and newborn ischemia, brain injuries, Alzheimer's disease, Parkinson's disease, Huntington's disease, and motor neuron disease.
-
Breast cancer can become more aggressive and difficult to treat due to the ID-1 gene. However, it was discovered in 2007 that Cannabidiol (CBD) can "neutralise" this gene. This important discovery was subsequently forgotten.
CBD, a cannabinoid with low toxicity, has been identified as a novel inhibitor of the ID-1 gene expression in aggressive breast cancer cells. Invasion and metastasis of these cells are the final and fatal steps during cancer progression, and are the least understood genetically. There are limited therapeutic interventions available for aggressive and metastatic breast cancers, hence the urgent need for effective and non-toxic treatments. CBD's ability to down-regulate the ID-1 gene expression in aggressive human breast cancer cells makes it a significant discovery.
In 2012, a study brought attention back to this discovery, highlighting how CBD not only stopped the cancer cells from behaving aggressively, but also helped revert them to a normal state. However, this only worked on cancer cells with high levels of ID-1.
Fast forward fifteen years, a repeat of the original study produced the same remarkable results; CBD caused the aggressive cells to revert to a normal state. In another study, CBD was found to block the progression of the inflammatory IL-1β-induced signaling pathway, which drives the transition to a malignant phenotype.
The surprising result is that the cancer cells appear to revert to normal cells. Contrasting this with chemotherapy, which aims to poison the cancer before it harms the patient, CBD seems like a promising alternative. Moreover, it has been suggested that CBD and other cannabinoids could potentially enhance the effectiveness of chemotherapy.
In a nutshell, the potential benefits of CBD in treating aggressive breast cancer are significantly undervalued.
-
Could my forgetfulness in taking my anti-depressants have been influenced by my consumption of CBD gummies? I stumbled upon a piece of information recently, which I shared with a friend who indulges in cannabis, but felt it was worth sharing here too, to avoid spreading any misconceptions.
In a research study on the Endocannabinoid System's role along with external cannabinoids in Depression and Anxiety, it was found that these cannabinoid compounds were as effective as some recognized anti-depressants they were compared with. Interestingly, these favourable effects on anxiety and depression were noticed at relatively low doses of cannabinoids that activate CB1R, while higher doses tended to have a depressive and anxiety-inducing effect.
In the wise words of Buddha, moderation is key.
-
A user referred to a comprehensive page on cannabinoids, specifically focusing on endocannabinoids' role in feeding behaviour and energy balance. They found the article lengthy, akin to a chapter, but expressed concerns over a particular statement about cannabidiol (CBD). The statement suggested that CBD doesn't significantly interact with CB1 or CB2 receptors, with its biological effects attributed to either the inhibition of anandamide degradation, antioxidant properties, or interactions with unidentified cannabinoid receptors. The user disagreed with this statement, citing another source indicating CBD has a higher affinity for CB2 than CB1. The user also mentioned conflicting research suggesting CBD's antagonist or agonist activity on CB2.
-
A pair's investigation into lung cancer-
Remarkable lung cancer response to self-administered cannabidiol: A case study and literature analysis. (UK) (full – 2019) Remarkable lung cancer response to self-administered cannabidiol: A case study and literature analysis
Despite advancements in medicine, lung cancer prognosis remains bleak. While targeted treatments have improved outcomes, it's not uncommon for many patients to only partially respond and relapse during follow-up. Therefore, the need for new drugs or reassessment of existing therapies for other non-cancerous diseases (drug repurposing) is urgent. It is critical, while conducting this research in vitro and in vivo, to remain observant of patients who show a positive response to non-standard treatments. We document here a lung adenocarcinoma patient who, having declined chemotherapy and radiotherapy, exhibited tumour response following self-administration of cannabidiol, a non-psychoactive compound in Cannabis sativa. Previous studies have suggested that cannabidiol may possess anti-cancer properties and boost the immune response to cancer. The data presented here suggest that cannabidiol may have induced a remarkable response in a lung cancer patient.
The use of the word "remarkable" in the title by the scientists is quite atypical. It appears their expectations were significantly exceeded!
Inhaled cannabidiol hinders tumour growth by reducing tumour stemness and impairing angiogenic switch in NCI-H1437-induced human lung cancer model. (USA/ Belgium) (abst – 2023) https://link.springer.com/article/10.1007/s13577-023-00869-8
Lung cancer remains the most persistent type of cancer and the primary cause of cancer death globally. Despite substantial advancements in lung cancer treatment, current therapeutic interventions are only partially successful, thus highlighting the need for more effective, innovative alternative treatments. Angiogenesis and cancer stem cells are critical in the onset and progression of cancers. Tumour angiogenesis is initiated by an angiogenic switch when pro-angiogenic factors surpass anti-angiogenic elements. Although numerous anti-angiogenic agents are used in cancer treatment, their therapeutic effectiveness is constrained by significant side effects. Recently, cannabinoids have been extensively studied for their potential anti-cancer effects. Our prior results indicated that cannabidiol (CBD) could hinder tumour growth in mouse models of melanoma and glioblastoma. Notably, CBD has been suggested to exhibit anti-angiogenic activity. In this study, we assessed, for the first time, inhaled CBD in the treatment of heterotopic lung cancer and whether such potential effects could decrease cancer stem cell numbers and inhibit tumour angiogenesis. We implanted NCI H1437 human lung cancer cells in nude mice and treated the mice with inhaled CBD or placebo. The results were evaluated by tumour size and imaging, as well as by immunohistochemistry and flow cytometric analysis for CD44, VEGF, and P-selectin. Our findings demonstrated that CBD reduced the tumour growth rate and suppressed the expression of CD44 and the angiogenic factors VEGF and P-selectin. These findings suggest, for the first time, that inhaled CBD can hinder lung cancer growth by suppressing CD44 and angiogenesis.
From Granny
-
I appreciate the information. I'm genuinely considering collecting as much scientific research as possible, hiring a truck, and delivering it all to a local Australian legislative assembly, saying, "Here's the research you requested." Now, the least they could do is legalize medicinal use. Some individuals are unable to use opioids for pain relief. Achieving significant outcomes like these requires people with your kind of dedication. If I were to personally make an appearance there... that may not end well.
-
This discussion focuses on the various advantages of cannabis I've previously noted. Feel free to contribute additional benefits.
-
The statement is about the potential of cannabis in promoting hair growth, which appears to be more effective than contemporary medical treatments. There's a case series that illustrates this using hemp extract. The results after only half a year are impressive, even for individuals who were previously bald, and it's not just effective for men, but women as well. This information was shared with a family member whose spouse is experiencing hair loss.
-
Galaxy420 shared a link to a webpage detailing Cannabinoid information, particularly on the topic of endocannabinoids and their role in managing feeding behaviour and energy balance. They found the article quite lengthy, akin to a chapter in a book. They expressed uncertainty regarding a statement in the article which suggested that cannabidiol doesn't interact significantly with CB1 or CB2 receptors. Their confusion also stems from different sources providing contrasting views on whether cannabidiol functions as an antagonist or an agonist.